VDR is a gene which encodes for a protein which acts as a receptor for vitamin D that regulates bone development and calcium absorption. A variant of the gene (rs2228570, FokI polymorphism) is associated with lower bone mineral density in white prepubescent girls.
The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is controlled by the reciprocal pattern and the temporal on-and-off occupancy of VDRE between the two components. It is also modulated by chromosomal locations and binding preferences for certain hormones. Microarray studies of human cells demonstrate that more than 100 genes possess an identifiable VDRE in their promoters. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.
A virtual dataroom (VDR) can serve gescheftmarketing.de/2021/09/01/how-much-icloud-storage-do-you-really-need/ as an archive of data and documents relevant to legal, business transactions or other proceedings. Viewing, downloading, or printing are restricted. It is accessed via central computers and an extranet which is a restricted-access Internet connection that allows users to access the internet at set times.
Companies involved in investment banking and in mergers and acquisitions are the most common users of a VDR. They must be able to share information in a transparent way with potential investors or buyers. Due diligence processes can also require a substantial amount of data. Life science companies also utilize VDRs to store everything from clinical trial results to HIPAA documentation.