The skeletal muscle relaxer cyclobenzaprine is a potent non-competitive antagonist of histamine H1 receptors Journal of Pharmacology and Experimental Therapeutics

There are options available across the full continuum of care to help with substance abuse. When certain drugs are used with cyclobenzaprine, they may cause more severe side effects such as increased drowsiness or sedation. A person should ask their doctor whether it is safe to combine another medication with cyclobenzaprine and take care not to operate any machinery while taking it.

  • In case of acute cyclobenzaprine overdose, emergency medicine physicians and triage nurses should stabilize the patient.
  • This medication has been prescribed for your current condition only.
  • Seizures should be controlled with benzodiazepines or, if these are ineffective, other anticonvulsants (e.g. phenobarbital, phenytoin).
  • At oral doses of up to 10 times the human dose, cyclobenzaprine did not adversely affect the reproductive performance or fertility of male or female rats.
  • To view formulary information first create a list of plans.
  • Among the most dreaded toxicities linked with cyclical antidepressants, overdoses affect fast-acting sodium channels in the cardiac conduction system.

These may include fatigue, nausea, headache, and general malaise. Side effects of benzodiazepines can include drowsiness and problems with balance and memory. Also, muscle relaxants depress your central nervous system (CNS), making it hard to pay attention or stay awake. While taking a muscle relaxant, avoid activities that require mental alertness or coordination, such as driving or using heavy machinery. Significance Statement Cyclobenzaprine, a clinically used muscle relaxant that is strongly linked to sedation, demonstrates high affinity non-competitive antagonism at the histamine H1 receptor. This effect likely modulates the high degree of sedation patients experience.

Skeletal muscle relaxants may also be used as an alternative to NSAIDs in patients who are at risk of gastrointestinal or renal complications. Abuse of muscle relaxants alone is uncommon; often, it involves other substances. The recommended dose of immediate-release cyclobenzaprine is 5 to 10mg, three times a day, while that for extended-release versions is 15 to 30 mg, once a day. Maximum daily dose for either form is 30 mg over the course of 24 hours. Taking more may result in adverse Flexeril side effects or overdose. Check with your doctor right away if you have anxiety, restlessness, a fast heartbeat, fever, sweating, muscle spasms, twitching, nausea, vomiting, diarrhea, or see or hear things that are not there.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use cyclobenzaprine only for the indication prescribed. Flexeril is usually taken once daily for only 2 or 3 weeks. Follow all directions on your prescription label and read all medication guides or instruction sheets.

Professional resources

Signs and symptoms of toxicity may develop rapidly after cyclobenzaprine overdose; therefore, hospital monitoring is required as soon as possible. The acute oral LD50 of FLEXERIL is approximately 338 and 425 mg/kg in mice and rats, respectively. The terms drug dependence and addiction are often used interchangeably; however, they are not the same thing. A dependence on a drug can occur independently of addiction.

Types of Skeletal Muscle Relaxers for Back Spasms – Verywell Health

Types of Skeletal Muscle Relaxers for Back Spasms.

Posted: Fri, 11 May 2018 03:07:58 GMT [source]

This medication has been prescribed for your current condition only. Do not use it later for another condition unless your doctor directs you to do so. During pregnancy, this medication should be used only when clearly needed.

Symptoms of overdose may include the following:

However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used flexeril and norco together together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco. Using this medicine with any of the following medicines is not recommended.

It is not known whether this drug is excreted in human milk. Because cyclobenzaprine is closely related to the tricyclic antidepressants, some of which are known to be excreted in human milk, caution should be exercised when FLEXERIL is administered to a nursing woman. Tricyclic antidepressants have been reported to produce arrhythmias, sinus tachycardia, prolongation of the conduction time leading to myocardial infarction and stroke. Less frequent dosing should be considered for hepatically impaired or elderly patients (see PRECAUTIONS, Impaired Hepatic Function, and Use in the Elderly). If you notice other effects not listed above, contact your doctor or pharmacist. Cyclobenzaprine is usually taken taken for up to 2 or 3 weeks.

Flexeril in particular is not even generally prescribed to the elderly population, according to the FDA, because of the high risk factors. You should talk to your doctor about the benefits and risks of these medications for the treatment of your muscle spasms. While antispasmodics can be used to treat muscle spasms, they have not been shown to work better than nonsteroidal anti-inflammatory drugs (NSAIDs) or acetaminophen. In addition, they have more side effects than NSAIDs or acetaminophen. Chemically, baclofen is related to gamma-aminobutyric acid (GABA), a naturally occurring neurotransmitter in the brain.

Ask your pharmacist any questions you have about refilling your prescription. Get professional help from an online addiction and mental health counselor from BetterHelp. In light of these findings, therapy with FLEXERIL in the elderly should be initiated with a 5 mg dose and titrated slowly upward.