Flexeril: Uses, Side Effects, Precautions, and some common FAQs

Cyclobenzaprine is best used in short-term treatment but may be used intermittently or long-term for chronic pain. Cyclobenzaprine belongs to a class of drugs called muscle relaxants. A class of drugs is a group of medications that work in a similar way.

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Do not use the extended-release capsules if you have used an MAO inhibitor (MAOI) such as Eldepryl®, Marplan®, Nardil®, or Parnate® within 14 days of each other. This medicine is available only with your doctor’s prescription. Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. During pregnancy, this medication should be used only when clearly needed. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy.

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The usual dose is 5–10mg three times daily and treatment for more than 2–3 weeks is not recommended. There is also a slight risk that abuse of Cyclobenzaprine or Flexeril can lead to serotonin syndrome. Serotonin syndrome occurs when you take medications that cause an excess of serotonin in your system.

  • Hyperpyretic crisis seizures, and deaths have occurred in patients receiving cyclobenzaprine (or structurally similar tricyclic antidepressants) concomitantly with MAO inhibitor drugs.
  • Sometimes, muscle relaxants like cyclobenzaprine are used “off-label” to treat conditions they’re not approved for, such as fibromyalgia.
  • For example, the peak concentration for the extended-release pills is around seven hours.
  • The recommended dose of immediate-release cyclobenzaprine is 5 to 10mg, three times a day, while that for extended-release versions is 15 to 30 mg, once a day.
  • Less frequent dosing should be considered for hepatically impaired or elderly patients (see PRECAUTIONS, Impaired Hepatic Function, and Use in the Elderly).

Please call our 24-hour hotline listed above if you need information about treatment for addiction to Flexeril or alcohol for yourself or for a loved one. Flexeril interacts with other medications and drugs that slow the brain’s processes, such as alcohol, barbiturates, benzodiazepines, and narcotics. Serious side effects of Flexeril include seizures, abnormal heartbeats, stroke, heart attacks, and heatstroke. Ask your healthcare professional how you should dispose of any medicine you do not use. If you miss a dose of this medicine, take it as soon as possible.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company. This medication has been prescribed for your current condition only. Do not use it later for another condition unless your doctor directs you to do so. Secondary endpoints included a physician’s evaluation of the presence and extent of palpable muscle spasm.

Cyclobenzaprine Overdose: Side Effects & Dangers of Abuse Flexeril

These patients are generally more susceptible to drugs with potentially sedating effects, including cyclobenzaprine. FLEXERIL should be used with caution in subjects with mild hepatic impairment starting with a 5 mg dose and titrating slowly upward. Due to the lack of data in subjects with more severe hepatic insufficiency, the use of FLEXERIL in subjects with moderate to severe impairment is not recommended.

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This can be harmful or prevent the drug from working well. Cyclobenzaprine oral tablet may cause drowsiness and dizziness. This is more likely to happen in the few hours after you take it. It isn’t known exactly how this drug works to relax your muscles.

Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. All patients suspected of an overdose with FLEXERIL should receive gastrointestinal decontamination. This should include large volume gastric lavage followed by activated charcoal. If consciousness is impaired, the airway should be secured prior to lavage and emesis is contraindicated. The plasma concentration of cyclobenzaprine is increased in patients with hepatic impairment (see CLINICAL PHARMACOLOGY, Pharmacokinetics, Hepatic Impairment). Tricyclic antidepressants have been reported to produce arrhythmias, sinus tachycardia, prolongation of the conduction time leading to myocardial infarction and stroke.

Pain Amplification Syndromes

If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Because of the possibility of higher blood levels in the elderly as compared to younger adults, use of cyclobenzaprine extended-release capsules is not recommended in the elderly. Appropriate studies have not been performed on the relationship of age to the effects of cyclobenzaprine extended-release capsules in the pediatric population. flexeril dosage adults Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Taking MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Avoid taking MAO inhibitors (isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) during treatment with this medication.

A number of treatment approaches are available to help treat Flexeril and alcohol addiction. The overall incidence of adverse reactions among patients in the surveillance program was less than the incidence in the controlled clinical studies. Cyclobenzaprine comes as a tablet and an extended-release capsule to take by mouth. The tablet is usually taken with or without food three times a day.